External data extracted from UniProtKB/Swiss-Prot |
Extracted from UniProtKB/Swiss-Prot, release: 0.0 |
Entry name | HCD2_HUMAN |
Primary accession number | Q99714 |
Secondary accession number(s) | Q5H927 Q6IBS9 Q8TCV9 Q96HD5 |
Sequence was last modified on | January 23, 2007 (version 3) |
Annotations were last modified on | March 15, 2017 (version 190) |
Name and origin of the protein |
Description | RecName: Full=3-hydroxyacyl-CoA dehydrogenase type-2; EC=1.1.1.35; AltName: Full=17-beta-hydroxysteroid dehydrogenase 10; Short=17-beta-HSD 10; EC=1.1.1.51; AltName: Full=3-hydroxy-2-methylbutyryl-CoA dehydrogenase; EC=1.1.1.178; AltName: Full=3-hydroxyacyl-CoA dehydrogenase type II; AltName: Full=Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; AltName: Full=Mitochondrial ribonuclease P protein 2; Short=Mitochondrial RNase P protein 2; AltName: Full=Short chain dehydrogenase/reductase family 5C member 1; AltName: Full=Short-chain type dehydrogenase/reductase XH98G2; AltName: Full=Type II HADH; |
Gene name | Name=HSD17B10 Synonyms=ERAB, HADH2, MRPP2, SCHAD, SDR5C1, XH98G2 |
Encoded on | Name=HSD17B10; Synonyms=ERAB, HADH2, MRPP2, SCHAD, SDR5C1, XH98G2 |
Keywords | 3D-structure; Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Disease mutation; Mental retardation; Mitochondrion; NAD; Oxidoreductase; Reference proteome; tRNA processing. |
Copyright |
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License |
Cross-references |
EMBL | U96132; AAC51812.1; -; mRNA |
EMBL | U73514; AAB68958.1; -; mRNA |
EMBL | AF069134; AAC39900.1; -; mRNA |
EMBL | AF035555; AAC15902.1; -; mRNA |
EMBL | AF037438; AAC16419.1; -; Genomic_DNA |
EMBL | CR456723; CAG33004.1; -; mRNA |
EMBL | Z97054; CAI42652.1; -; Genomic_DNA |
EMBL | Z97054; CAI42653.1; -; Genomic_DNA |
EMBL | CH471154; EAW93157.1; -; Genomic_DNA |
EMBL | CH471154; EAW93158.1; -; Genomic_DNA |
EMBL | BC000372; AAH00372.1; -; mRNA |
EMBL | BC008708; AAH08708.1; -; mRNA |
EMBL | AY092415; AAM18189.1; -; mRNA |
CCDS | CCDS14354.1; -. [Q99714-1]; . |
CCDS | CCDS35300.1; -. [Q99714-2]; . |
RefSeq | NP_001032900.1; NM_001037811.2. [Q99714-2]; . |
RefSeq | NP_004484.1; NM_004493.2. [Q99714-1]; . |
UniGene | Hs.171280; -; . |
PDB | 1F67; Model; -; A=1-261 |
PDB | 1SO8; X-ray; 2.30 A; A=1-261 |
PDB | 1U7T; X-ray; 2.00 A; A/B/C/D=1-261 |
PDB | 2O23; X-ray; 1.20 A; A/B=1-261 |
PDBsum | 1F67; -; . |
PDBsum | 1SO8; -; . |
PDBsum | 1U7T; -; . |
PDBsum | 2O23; -; . |
ProteinModelPortal | Q99714; -; . |
SMR | Q99714; -; . |
BioGrid | 109278; 243; . |
IntAct | Q99714; 26; . |
MINT | MINT-3059664; -; . |
STRING | 9606.ENSP00000168216; -; . |
ChEMBL | CHEMBL4159; -; . |
DrugBank | DB00157; NADH; . |
SwissLipids | SLP:000000787; -; . |
iPTMnet | Q99714; -; . |
PhosphoSitePlus | Q99714; -; . |
SwissPalm | Q99714; -; . |
BioMuta | HSD17B10; -; . |
DMDM | 2492759; -; . |
REPRODUCTION-2DPAGE | IPI00017726; -; . |
REPRODUCTION-2DPAGE | Q99714; -; . |
UCD-2DPAGE | Q99714; -; . |
EPD | Q99714; -; . |
MaxQB | Q99714; -; . |
PaxDb | Q99714; -; . |
PeptideAtlas | Q99714; -; . |
PRIDE | Q99714; -; . |
TopDownProteomics | Q99714-1; -. [Q99714-1]; . |
TopDownProteomics | Q99714-2; -. [Q99714-2]; . |
DNASU | 3028; -; . |
Ensembl | ENST00000168216; ENSP00000168216; ENSG00000072506. [Q99714-1]; . |
Ensembl | ENST00000375304; ENSP00000364453; ENSG00000072506. [Q99714-2]; . |
GeneID | 3028; -; . |
KEGG | hsa:3028; -; . |
UCSC | uc004dsl.2; human. [Q99714-1]; . |
CTD | 3028; -; . |
DisGeNET | 3028; -; . |
GeneCards | HSD17B10; -; . |
HGNC | HGNC:4800; HSD17B10; . |
HPA | HPA001432; -; . |
MalaCards | HSD17B10; -; . |
MIM | 300220; phenotype; . |
MIM | 300256; gene; . |
MIM | 300438; phenotype; . |
MIM | 300705; phenotype; . |
neXtProt | NX_Q99714; -; . |
OpenTargets | ENSG00000072506; -; . |
Orphanet | 85295; HSD10 disease; atypical type; . |
Orphanet | 391428; HSD10 disease; infantile type; . |
Orphanet | 391457; HSD10 disease; neonatal type; . |
PharmGKB | PA162391638; -; . |
eggNOG | KOG1199; Eukaryota; . |
eggNOG | ENOG410XNNW; LUCA; . |
GeneTree | ENSGT00760000118868; -; . |
HOVERGEN | HBG002145; -; . |
InParanoid | Q99714; -; . |
KO | K08683; -; . |
OMA | LMGLVNC; -; . |
OrthoDB | EOG091G0G9O; -; . |
PhylomeDB | Q99714; -; . |
TreeFam | TF354307; -; . |
BioCyc | MetaCyc:HS01071-MONOMER; -; . |
BRENDA | 1.1.1.178; 2681; . |
BRENDA | 1.1.1.35; 2681; . |
Reactome | R-HSA-6785470; tRNA processing in the mitochondrion; . |
Reactome | R-HSA-6787450; tRNA modification in the mitochondrion; . |
Reactome | R-HSA-70895; Branched-chain amino acid catabolism; . |
Reactome | R-HSA-8868766; rRNA processing in the mitochondrion; . |
SABIO-RK | Q99714; -; . |
ChiTaRS | HSD17B10; human; . |
EvolutionaryTrace | Q99714; -; . |
GeneWiki | HSD17B10; -; . |
GenomeRNAi | 3028; -; . |
PRO | PR:Q99714; -; . |
Proteomes | UP000005640; Chromosome X; . |
Bgee | ENSG00000072506; -; . |
CleanEx | HS_HSD17B10; -; . |
ExpressionAtlas | Q99714; baseline and differential; . |
Genevisible | Q99714; HS; . |
GO | GO:0005737; C:cytoplasm; TAS:ProtInc; . |
GO | GO:0005759; C:mitochondrial matrix; TAS:Reactome; . |
GO | GO:0005739; C:mitochondrion; ISS:UniProtKB; . |
GO | GO:0005886; C:plasma membrane; TAS:ProtInc; . |
GO | GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC; . |
GO | GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; EXP:Reactome; . |
GO | GO:0008709; F:cholate 7-alpha-dehydrogenase activity; TAS:ProtInc; . |
GO | GO:0003723; F:RNA binding; IDA:UniProtKB; . |
GO | GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; IEA:UniProtKB-EC; . |
GO | GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome; . |
GO | GO:0006629; P:lipid metabolic process; TAS:ProtInc; . |
GO | GO:0070901; P:mitochondrial tRNA methylation; TAS:Reactome; . |
GO | GO:0090646; P:mitochondrial tRNA processing; TAS:Reactome; . |
Gene3D | 3.40.50.720; -; 1; . |
InterPro | IPR016040; NAD(P)-bd_dom; . |
InterPro | IPR020904; Sc_DH/Rdtase_CS; . |
InterPro | IPR002347; SDR_fam; . |
Pfam | PF00106; adh_short; 1; . |
PRINTS | PR00081; GDHRDH; . |
PRINTS | PR00080; SDRFAMILY; . |
SUPFAM | SSF51735; SSF51735; 1; . |
PROSITE | PS00061; ADH_SHORT; 1; . |